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. 2017 Oct 23;8(60):101984–101993. doi: 10.18632/oncotarget.21957

Figure 4. MiR-509-5p expression was directly regulated by MALAT1.

Figure 4

(A) The predicted binding sites between MALAT1 and miR-509-5p. (B) Dual-luciferase reporter assay revealed that miR-509-5p mimics decreased luciferase activity of MALAT1-Wt, but not of MALAT1-mut. (C) Relative expression of miR-509-5p in MM samples was determined by qRT-PCR. (D) Pearson's correlation analysis between miR-509-5p expression and MALAT1 expression in MM samples. (E) miR-509-5p expression in MALAT1 decreased MM cells was determined by qRT-PCR. (F) MALAT1 expression in miR-509-5p mimics transfected MM cells was determined by qRT-PCR. (G, H) RNA-IP assays were performed in MM cells transfected with miR-509-5p mimics and miR-NC. ** P<0.01; * P < 0.05.