Figure 7. The OBSCN gene involved either direct or indirect pathway of GPCR, Ras, p75 or Wnt signaling.

(In GPCR pathway, OBSCN-RhoGEF is simultaneously regulates mDIA, Rho and their downstream genes which are involved in cell differentiation and lamellipodia formation; the other chain of OBSCN, MLCK and its downstream pathway activates MLC leads to formation of stress fiber which cause cell differentiation and survival; On the other way RhoA activated from p75 (NTR) pathway also involved in Ras pathway regulates down regulates MLCK; in Wnt signaling OBSCN disequilibrium leads to β-catenin loss which leads to carcinogenesis.