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. 2017 May 23;8(60):102600–102616. doi: 10.18632/oncotarget.18126

Figure 3. Secretome of mesenchymal stem cells.

Figure 3

After activation, mesenchymal stem cells (MSCs) can produce various growth factors (KGF, HGF, and EGF) to protect epithelium function. MSCs enhance endothelium barrier via NO, S1P, Ang-1, and VEGF and secrete anti-inflammatory cytokines, such as IL-1ra, IL-10, and TSG-6. Moreover, MSCs achieve immunomodulating function through chemokines and receptors (ICAM-1, VCAM-1, and CXCR3). These factors are crucial components for function regulation and tissue repair by MSCs. Abbreviations: KGF: keratinocyte growth factor; HGF: hepatocyte growth factor; EGF: epidermal growth factor; NO: nitric oxide; S1P: sphingosine-1-phosphate; Ang-1: angiopoietin-1; VEGF: vascular endothelial growth factor; TSG-6: TNF-α stimulated gene/protein 6; PGE2: prostaglandin E2; IL-1ra: IL-1 receptor antagonist; IL-10: interleukin-10; IGF-1: insulin like growth factor 1; TGF-β: transforming growth factor-β; ICAM-1: intercellular adhesion molecule-1; VCAM-1: vascular cell adhesion molecule-1.