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. 2017 Oct 19;8(60):102721–102738. doi: 10.18632/oncotarget.21970

Figure 2. Diagram illustrating the SDF-1 signaling pathways.

Figure 2

There are several SDF-1 signaling pathways involving with the malignant development of PDAC, which play the role in invasion, metastasis, metabolic genes expression and chemoresistance to GEM. In addition, SDF-1 participates in the formation of pre-metastatic niche in lung and liver cancers, but this process is not yet clear in PDAC. NRF2, nuclear factor erythroid 2; SMO, Smoothened; FAK, focal adhesion kinase; ERK, extracellular signal-regulated protein kinases; GEM, gemcitabine.