Table 2.
List of the most enriched biological processes associated with hnRNP K target mRNAs
| GO biological process | Rattus novergicus (reference list) | Uploaded list | (Expected) | (Over/under) | fold enrichment | (p value) |
|---|---|---|---|---|---|---|
| Glutamate receptor signaling pathway | 44 | 39 | 17.26 | + | 2.26 | 3.81E-02 |
| Amino acid transport | 90 | 76 | 35.31 | + | 2.15 | 1.46E-05 |
| Synapse assembly | 51 | 43 | 20.01 | + | 2.15 | 4.35E-02 |
| Dendrite morphogenesis | 57 | 48 | 22.36 | + | 2.15 | 1.34E-02 |
| Dendrite development | 106 | 89 | 41.58 | + | 2.14 | 8.56E-07 |
| Regulation of neuronal synaptic plasticity | 71 | 59 | 27.85 | + | 2.12 | 1.46E-03 |
| Regulation of synaptic plasticity | 181 | 148 | 71.00 | + | 2.08 | 6.28E-12 |
| Forebrain cell migration | 70 | 57 | 27.46 | + | 2.08 | 4.35E-03 |
| Regulation of dendrite morphogenesis | 94 | 76 | 36.88 | + | 2.06 | 8.66E-05 |
| Telencephalon cell migration | 67 | 54 | 26.28 | + | 2.05 | 1.14E-02 |
| Positive regulation of dendrite development | 91 | 73 | 35.70 | + | 2.04 | 2.24E-04 |
| Negative regulation of synaptic transmission | 64 | 51 | 25.11 | + | 2.03 | 2.96E-02 |
| Learning | 159 | 126 | 62.37 | + | 2.02 | 6.53E-09 |
| Regulation of synapse structure or activity | 280 | 221 | 109.84 | + | 2.01 | 3.29E-17 |
| Positive regulation of synapse assembly | 66 | 52 | 25.89 | + | 2.01 | 3.27E-02 |
| Synaptic vesicle cycle | 94 | 74 | 36.88 | + | 2.01 | 3.75E-04 |
| Regulation of postsynaptic membrane potential | 65 | 51 | 25.50 | + | 2.00 | 4.48E-02 |
| Neurotransmitter secretion | 102 | 80 | 40.01 | + | 2.00 | 1.29E-04 |
| Signal release from synapse | 102 | 80 | 40.01 | + | 2.00 | 1.29E-04 |
| Regulation of synapse assembly | 83 | 65 | 32.56 | + | 2.00 | 2.79E-03 |
| Presynaptic process involved in chemical synaptic transmission | 106 | 83 | 41.58 | + | 2.00 | 7.57E-05 |
More detailed information is provided in Extended Data Tables 1-1–1-8: Table 1-1, hnRNP K coimmunoprecipitated transcripts; Table 1-2, biological processes associated with mRNAs coimmunoprecipitated with hnRNP K as assessed by GO; Table 1-3, cellular components associated with mRNAs coimmunoprecipitated with hnRNP K as assessed by GO; Table 1-4, molecular functions associated with mRNAs coimmunoprecipitated with hnRNP K as assessed by GO; Table 1-5, hnRNP K coimmunoprecipitated transcripts regulated by BDNF; Table 1-6, biological processes associated with mRNAs coimmunoprecipitated with hnRNP K and regulated by BDNF as assessed by GO; 1-7, cellular components associated with mRNAs coimmunoprecipitated with hnRNP K and regulated by BDNF as assessed by GO; 1-8, molecular functions associated with mRNAs coimmunoprecipitated with hnRNP K and regulated by BDNF as assessed by GO.