Table 2.
Relationship between neuropsychological variables and total tau burden
| Features | N | PSP | Spearman’s rho | P value |
|---|---|---|---|---|
| Age at Testing, years | 37 | 71 ± 8 | −0.49 | 0.002 |
| Age at Disease Onset, years | 36 | 67 ± 8 | −0.49 | 0.008 |
| Age at Death, years | 37 | 75 ± 8 | −0.44 | 0.006 |
| Education Level, years | 37 | 15 ± 3 | −0.12 | 0.49 |
| Global Cognitive Functioning | ||||
| Overall Test Battery Mean | 32 | 40 (34, 48) | −0.49 | 0.005* |
| DRS-2 Total Score | 33 | 33 (23, 47) | −0.47 | 0.006* |
| Attention/Processing Speed | 32 | 45 (37, 49) | −0.42 | 0.02 |
| Executive Functioning | 32 | 37 (28, 46) | −0.51 | 0.003* |
| Episodic Memory | 32 | 44 (35, 54) | −0.46 | 0.008 |
| Language | 32 | 43 (37, 47) | −0.31 | 0.09 |
| Visuospatial/Construction | 32 | 43 (35, 47) | −0.033 | 0.86 |
All test scores are shown as standardized age-corrected T-scores (M = 50, SD = 10). Spearman’s rho is calculated as a correlation between each score and total tau burden.
*
indicates statistical significance after applying a Bonferroni correction for multiple testing in neuropsychological scores (P < 0.0071).