Table 3.

Summary of the Findings for the Longitudinal Associations (Within-Subject Effect) Between Indices of Depression, SSRI use, and GAD on the One Hand and Skeletal Outcomes on the Other

	MDD Indices		SSRI Indices		GAD Indices
	Males	Females	Males	Females	Males	Females
TBLH aBMC Z-score	~	~	~	~	~	~
LS aBMD Z-score	↑	↑	↓	↑	~	↑
Trabecular vBMD	~	~	~	~	~	~
Polar Section Modulus	~	↓	~	↑	~	↓
Bone Formation Relative to Bone Resorption	↓	~	~	↑	~	~

MDD: Major depressive disorder, SSRI: Selective serotonin reuptake inhibitors, GAD: Generalized anxiety disorder, TBLH aBMC Z-score: Total body less head areal bone mineral content age-sex-race-height-specific Z-score. LS aBMD Z-score: Lumbar spine areal bone mineral density age-sex-race-height-specific Z-score. vBMD: Volumetric bone mineral density.

^~Denotes the absence of any significant longitudinal association. ↑: Denotes the presence of a significant positive association between the predictors of interest and the slope of the outcome. ↓: Denotes the presence of a significant inverse association between the predictors of interest and the slope of the outcome.