Table 1.

Current clinical studies with interventions into to the regulation of the prolactin/vasoinhibin axis.

Disease	Clinical pathology	Proposed pathomechanism	Therapeutic intention	Therapeutic strategy	Drug	ClinicalTrials.gov Identifier
Diabetic retinopathy and diabetic macular edema	Retinal edema	Increase in retinal vasopermeability	Inhibition of retinal vasopermeability by vasoinhibins	Increase PRL-secretion by dopamine D2-receptor antagonism	Levosulpiride	NCT03161652
Peripartum cardiomyopathy	Low left ventricular ejection fraction	Vasoinhibin-mediated damage of myocardial vascularization	Inhibition of vasoinhibin generation in the heart	Inhibition of PRL-secretion by dopamine D2-receptor agonism	Bromocriptine	NCT00998556