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. 2017 Dec 11;8:1719. doi: 10.3389/fimmu.2017.01719

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Copyright © 2017 Battu, Minhas, Mishra and Khan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amino acid sensing and cellular Th17-immune responses. General control nonderepressible-2 kinase (GCN2)-mediated amino acid sensing is also known to dampen the Th17 immune responses by inhibiting the STAT3 transcription factor, essential for Th17 response and simultaneously by hindering the mTORC1 activity, which is known to facilitate Th17 differentiation via S6K2 activation followed by nuclear translocation of RORγ. The GCN2 activation also leads to activation and differentiation of the regulatory T cells.