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. 2017 Dec 11;4:78. doi: 10.3389/fcvm.2017.00078

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Copyright © 2017 Bakhshian Nik, Hutcheson and Aikawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophage-derived extracellular vesicles (EVs) within atherosclerotic cap. (A) Macrophage-derived EVs contain the CD68 glycoprotein (immunogold staining); (B) released EVs have various size and morphology and aggregate to build calcific mineral within the atherosclerotic fibrous cap (63).