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. 2017 Dec 15;7:17624. doi: 10.1038/s41598-017-17912-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The Biocage and its relative size. (a) Light microscopy image of the Biocage device showing its relative proportions and porous exterior. Scale bar = 100 µm. (b and c) Relative size of the Biocage. Biocage from the top-down viewpoint is displayed in relation to a pencil tip (to the left) and dime (to the right) to reflect its miniature size. (c) is a higher magnification of the boxed area in (b). (d) Schematic of the workflow for implantation of the Biocage. Biocages are first filled with the desired therapeutic molecules and capped. The device is then inserted into the targeted tissue of interest (in our example, a mouse cortex). The contents are allowed to elute into the local surrounding areas of the tissue.