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. 2017 Dec 15;7:17624. doi: 10.1038/s41598-017-17912-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CAD design for the Biocage. (a) Oblique angle view of the Biocage. Its design is a 300 µm empty hollow inner diameter to be filled, a 20 µm outer wall, a 40 µm solid base, and a 900 µm total height. The outer wall is perforated with holes, each with a diameter of 5 µm. (b) Side profile of the Biocage. (c) Top profile of the Biocage showing the holes perforating through the outer wall. (d) Higher magnification of pores of the Biocage showing dimensions.