Figure 1.

Multivariate analysis (OPLS-DA) of CSF lipids in patients with ALS and controls (n = 85) based on 19 lipids (p = 0.005). (A) Score scatter plot. Blue dots: patients with ALS; green dots: controls. X-axis and Y-axis represent score vectors summarizing all the variables entering the analysis: t1 and to1; R ² X(cum) = 86.8% R ² Y(cum) = 59.0%, Q ²(cum) = 0.402 (B) Loading scatter plot. Variables near each other are positively correlated; variables opposite to each other are negatively correlated. Variables closer to dots corresponding to “ALS” or “Controls” dots (i.e. with the largest absolute loading values) are higher in the corresponding populations. Lipids from the same family are represented with the same color.