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. 2017 Dec 11;8:1765. doi: 10.3389/fimmu.2017.01765

Figure 1.

Figure 1

Bone marrow-derived dendritic cell (BMDC) incubated with activated lymphocyte-derived DNA (ALD-DNA) induced mice lupus symptom. (A) Total IgG against ds-DNA in sera from the mice that transferred with: (left to right) positive control group (I.H.ALD-DNA): subcutaneously immunized ALD-DNA with adjuvant; negative control group: PBS, BMDCs; experimental group: BMDCs-ALD-DNA. (B) Urine protein levels of lupus mice on week 6 post BMDCs-ALD-DNA or the control substances transferred were assessed by visual urine test paper. (C) The gross appearance and the weight of spleens or lymph nodes from the control group mice and the experimental group mice, the mice were sacrificed on week 20 post BMDCs-ALD-DNA or the control substances transferred to get the spleens and the kidneys. (D–F) Histology (D) and total IgG (E) or C3 (F) glomerular deposition of kidney from the control group and the experimental group mice. The mice were sacrificed on week 20 after the BMDCs or the control substances transferred. Representative result from each group of five mice is shown. Values represent means ± SEM (*p < 0.05, ***p < 0.0005). Scale bar: 100 µm.