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. 2017 Dec 11;8:1765. doi: 10.3389/fimmu.2017.01765

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Copyright © 2017 Xiao, Zheng, Hu, Wang, Olsen and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B7-H4-deficient C57BL/6-lpr/lpr mice develop exacerbated lupus symptom. (A–E) Total IgG against ds-DNA in sera (A) and the gross appearance and the weight (B) of spleens or lymph nodes and histology (C) and total IgG (D) or C3 (E) glomerular deposition of kidney from the C57BL/6-lpr/lpr mice and the B7-H4 knockout (B7-H4-KO) lpr mice. (F) Total IgG against ds-DNA in sera of the C57BL/6-lpr/lpr mice with mouse Ig or 6H3 treatment. The mice were sacrificed on week 30 post BMDCs-ALD-DNA or the control substances transferred to get the spleens and the kidneys. Representative result from each group of five mice is shown. Values represent means ± SEM (**p < 0.005, ***p < 0.0005). Scale bar: 100 µm.