Figure 1.

Study design for the rat unilateral labyrinthectomy (UL) model. (A) The timeline illustrates the different assessments and modalities in relation to the day of surgery. (B) The upper image represents a typical summed 60–90 min [¹⁸F]GE180 PET scan of the rat head in the axial direction. Localization of UL with corresponding translocator protein (TSPO) activation in the inner ear is indicated by a white circle. The white stippled line represents the position of the intact brain. The lower image represents a typical [¹⁸F]GE180 autoradiography slice of the brainstem, where elevated TSPO activity in the vestibular nucleus is highlighted with a red arrow. L, left; R, right.