Table 1.
Demographic and treatment characteristics of survivors of childhood acute lymphoblastic leukemia from the PETALE cohort.
| Characteristic | Total (N = 247) | PETALE | |
|---|---|---|---|
| Adults (N = 162) | Children (N = 85) | ||
| Gender, N (%) | |||
| Male | 122 (49.4) | 80 (49.4) | 42 (49.4) |
| Female | 125 (50.6) | 82 (50.6) | 43 (50.6) |
| Age at interview, years | |||
| Mean (SD) | 22.1 (6.3) | 25.5 (5.1) | 15.7 (1.8) |
| Median (range) | 21.7 (8.5–41.0) | 24.7 (18.0–41.0) | 16.2 (8.5–17.9) |
| Age at cancer diagnosis, y | |||
| Mean (SD) | 6.6 (4.6) | 7.9 (5.0) | 4.2 (2.2) |
| Median (range) | 4.7 (0.8–18.0) | 6.5 (0.8–18.0) | 3.6 (1.2–11.0) |
| Time from diagnosis, y | |||
| Mean (SD) | 15.5 (5.2) | 17.7 (5.0) | 11.5 (2.5) |
| Median (range) | 15.2 (5.4–28.2) | 18.3 (6.2–28.2) | 11.9 (5.4–15.6) |
| Risk groups, N (%) | |||
| Standard risk | 113 (45.8) | 59 (36.4) | 54 (63.5) |
| High risk | 128 (51.8) | 100 (61.7) | 28 (32.9) |
| Very high risk | 6 (2.4) | 3 (1.9) | 3 (3.53) |
| Treatment protocol, N (%) | |||
| DFCI 87–01 | 24 (9.7) | 24 (14.8) | 0 (0.0) |
| DFCI 91–01 | 46 (18.6) | 46 (28.4) | 0 (0.0) |
| DFCI 95–01 | 73 (29.6) | 56 (34.6) | 17 (20.0) |
| DFCI 2000–01 | 77 (31.2) | 21 (13.0) | 56 (65.9) |
| DFCI 2005–01 | 27 (10.9) | 15 (9.3) | 12 (14.1) |
| CRT exposure, N (%) | |||
| Total | 147 (59.5) | 113 (69.8) | 34 (40.0) |
| DFCI 87–01 | 18 (7.3) | 18 (11.1) | 0 (0.0) |
| DFCI 91–01 | 37 (15.0) | 37 (22.8) | 0 (0.0) |
| DFCI 95–01 | 45 (18.2) | 34 (21.0) | 11 (12.9) |
| DFCI 2000–01 | 33 (13.4) | 17 (10.5) | 16 (18.8) |
| DFCI 2005–01 | 14 (5.7) | 7 (4.3) | 7 (8.2) |
CRT, cranial radiation therapy; DFCI, Dana Farber Cancer Institute. CRT doses were ranging between 10 and 20 gray.