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. 2017 Dec 15;7:17626. doi: 10.1038/s41598-017-17977-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced proteasome activity in MPM cell lines with increased sensitivity to bortezomib. (A) Chymotrypsin-like, trypsin-like, and caspase-like specific activities of proteasomes were assessed in cell extracts as described in the Materials and Methods and expressed on a per-cell basis. Data are the mean of six independent measurements. **P < 0.01. (B) Correlations of 26S proteasome peptidase activities and EC₅₀ values relative to the apoptotic effect of bortezomib in MPM cell lines.