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Stable recombinant α-synuclein dimers. (A) Domain diagram of monomeric human α-synuclein. (B) Diagrams of the α-synuclein dimers used in this study. CC dimer brings together the C-termini of two α-synuclein molecules via disulfide bonds. NC dimer was generated by engineering two copies of α-synuclein in tandem to generate a single polypeptide. (C) Coomassie stained 12% SDS-PAGE gel showing α-synuclein monomer and dimers and their respective molecular weights.
