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. 2017 Dec 15;7:17656. doi: 10.1038/s41598-017-18024-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Strychnine, an antagonist of the glycine receptor induces the same effects as extracellular cGMP on membrane expression and occludes the effect of cGMP on membrane expression of GluA1 and GluA2. Strychnine (75 µM), an antagonist of glycine receptor, alone or in combination with extracellular cGMP (40 nM) were added to cerebellar slices, and membrane expression of GluA1 (A and C) and GluA2 (B and D) subunits were analyzed as described in Methods. Values are expressed as percentage of basal and are the mean ± SEM of 8–16 rats (in A and B) and of 7–12 rats (in C and D). The unpaired Student’s t-test and non-parametric Kruskal-Wallis test were performed to compare two or more groups, respectively. Values significantly different from basal are indicated by asterisks *p < 0.05, **p < 0.01, ***p < 0.001.