Table 1.
Summary of principal urethane data set
| ICL | ICNL | MGBL | MGBNL | ACL | ACNL | |
|---|---|---|---|---|---|---|
| Neurons | 26 | 56 | 25 | 33 | 34 | 36 |
| Points/required | 149/104 | 523/401 | 79/69 | 211/153 | 250/125 | 307/29 |
| DEV (spikes) | 1.37 | 0.99 | 0.72 | 0.69 | 0.95 | 0.98 |
| STD (spikes) | 1.25 | 0.22 | 0.20 | 0.16 | 0.24 | 0.21 |
| Cascade (spikes) | 1.66 | 0.97 | 0.74 | 0.57 | 0.77 | 0.59 |
| Many-standards (spikes) | 1.91 | 0.95 | 0.90 | 0.65 | 0.85 | 0.52 |
| Spike count differences | ||||||
| DEV−STD | 0.12 | 0.78 | 0.52 | 0.54 | 0.71 | 0.76 |
| p value | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| Cascade−STD | 0.41 | 0.76 | 0.53 | 0.42 | 0.53 | 0.38 |
| p value | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| DEV−Cascade | −0.29 | 0.02 | −0.01 | 0.12 | 0.18 | 0.38 |
| p value | 0.000 | 0.024 | 0.021 | 0.019 | 0.017 | 0.000 |
| Many-standards−STD | 0.57 | 0.73 | 0.70 | 0.50 | 0.60 | 0.31 |
| p value | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| DEV−Many-standards | 0.04 | 0.04 | −0.26 | 0.03 | 0.11 | 0.46 |
| p value | 0.190 | 0.155 | 0.003 | 0.671 | 0.049 | 0.000 |
| Differences using Cascade controls | ||||||
| iMM | 0.14 | 0.49 | 0.34 | 0.52 | 0.50 | 0.60 |
| p value | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| iRS | 0.22 | 0.46 | 0.46 | 0.46 | 0.39 | 0.33 |
| p value | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| iPE | −0.08 | 0.03 | −0.12 | 0.06 | 0.11 | 0.27 |
| p value | 0.000 | 0.024 | 0.021 | 0.019 | 0.017 | 0.000 |
| Differences using Many-standards | ||||||
| iMM | 0.14 | 0.48 | 0.30 | 0.50 | 0.50 | 0.61 |
| p value | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| iRS | 0.16 | 0.46 | 0.44 | 0.49 | 0.43 | 0.34 |
| p value | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
| iPE | −0.02 | 0.02 | −0.14 | 0.01 | 0.07 | 0.27 |
| p value | 0.190 | 0.155 | 0.003 | 0.671 | 0.049 | 0.000 |
For each auditory station: Number of recorded neurons and tested neuron/tone combinations (points), along with estimated minimum sample size (of points) required for a statistical power of 0.8 (see Methods subsection on ‘Statistical Analyses’). Median values for baseline-corrected spike counts (spikes) to the different conditions. Median differences between the former measures, and associated p values against zero (Friedman test with post hoc multiple comparison, Fisher’s Least Significant Difference method, uncorrected for 6 independent tests). All p values are rounded to 3 decimal figures, so a value of 0.000 means “p < 0.0005”. Median indices of neuronal mismatch (iMM), repetition suppression (iRS) and prediction error (iPE), computed from each of the two control sequences (cascade or many-standards), and their corresponding p values (note that p values are the same for absolute differences and normalized indices, since these indices are median differences between normalized responses, and the non-parametric test is independent of scaling). Values related to predictive neuronal activity are highlighted in bold case, since they represent the most significant result of this research