Table 3.

Logistic regression analysis for the association between hyperuricemia (HU) and individual amino acids for different groups of subjects without lifestyle-related diseases (no-LSRD) and with diabetes mellitus (DM), dyslipidemia, hypertension and metabolic syndrome (MetS) with adjustment for relevant potential confounding demographic and clinical factors: no-LSRD for age, gender, BMI, SBP, DBP, FPG, HbA1c, LDL-C, HDL-C and TG; DM for age, gender, BMI, SBP, DBP, LDL-C, HDL-C, TG and medication; dyslipidemia for age, gender, BMI, SBP, DBP, FPG, HbA1c and medication; hypertension for age, gender, BMI, FPG, HbA1c, LDL-C, HDL-C, TG and medication; and MetS for age, gender, BMI and medication. The odds ratios (OR) with 95% confidence intervals (CI) were estimated per IQR change in the concentrations of corresponding amino acids.

Aminoacid	No-LSRD				DM				Dyslipidemia				Hypertension				MetS
	(HU: no, 2613; yes, 192)				(HU: no, 362; yes, 53)				(HU: no, 2655; yes, 552)				(HU: no, 2261; yes, 475)				(HU: no, 509; yes, 208)
	OR	95% CI		p-value	OR	95% CI		p-value	OR	95% CI		p-value	OR	95% CI		p-value	OR	95% CI		p-value
		Lower	Upper			Lower	Upper			Lower	Upper			Lower	Upper			Lower	Upper
Ala	0.91	0.72	1.15	0.417	1.20	0.76	1.91	0.430	1.28	1.09	1.51	0.003	1.07	0.90	1.27	0.430	0.90	0.71	1.13	0.374
Arg	0.76	0.60	0.96	0.024	0.93	0.60	1.43	0.739	0.93	0.81	1.07	0.304	1.02	0.88	1.18	0.816	1.06	0.84	1.32	0.642
Asn	0.73	0.58	0.91	0.007	0.94	0.63	1.40	0.745	0.94	0.82	1.08	0.364	1.02	0.88	1.18	0.805	1.11	0.89	1.39	0.348
Cit	1.32	1.05	1.65	0.016	1.37	0.98	1.92	0.068	1.16	1.01	1.33	0.036	1.24	1.07	1.42	0.003	1.34	1.09	1.64	0.005
Gln	0.66	0.52	0.83	<0.001	0.68	0.45	1.03	0.069	0.78	0.68	0.89	<0.001	0.88	0.76	1.02	0.099	0.99	0.80	1.23	0.945
Gly	0.71	0.56	0.90	0.004	0.79	0.52	1.19	0.253	0.73	0.63	0.84	<0.001	0.88	0.76	1.01	0.076	0.84	0.70	1.01	0.071
His	0.97	0.79	1.20	0.808	1.37	0.94	2.00	0.100	1.12	0.99	1.26	0.071	1.21	1.04	1.40	0.012	1.10	0.94	1.29	0.238
Ile	1.45	1.16	1.81	0.001	1.36	0.86	2.16	0.187	1.63	1.36	1.94	<0.001	1.46	1.22	1.75	<0.001	1.40	1.08	1.82	0.012
Leu	1.74	1.33	2.26	<0.001	1.97	1.19	3.24	0.008	1.82	1.50	2.21	<0.001	1.53	1.25	1.88	<0.001	1.48	1.13	1.93	0.004
Lys	0.99	0.78	1.26	0.934	1.56	1.04	2.35	0.031	1.12	0.98	1.28	0.097	1.20	1.03	1.40	0.017	1.25	1.00	1.55	0.046
Met	0.82	0.64	1.04	0.099	1.01	0.66	1.53	0.971	1.04	0.89	1.21	0.644	1.08	0.92	1.27	0.330	1.16	0.93	1.45	0.183
Orn	1.07	0.86	1.33	0.544	1.12	0.77	1.64	0.549	1.11	0.99	1.25	0.075	1.13	1.00	1.28	0.047	1.21	0.99	1.46	0.059
Phe	1.27	1.03	1.56	0.026	1.82	1.24	2.66	0.002	1.34	1.18	1.53	<0.001	1.45	1.26	1.67	<0.001	1.68	1.34	2.10	<0.001
Pro	0.89	0.73	1.09	0.271	1.20	0.78	1.85	0.404	1.18	1.04	1.34	0.010	1.09	0.94	1.26	0.265	1.22	1.00	1.49	0.047
Ser	0.51	0.39	0.66	<0.001	0.57	0.37	0.88	0.011	0.57	0.49	0.66	0.000	0.70	0.60	0.83	<0.001	0.68	0.54	0.86	0.001
Thr	0.74	0.59	0.93	0.011	0.93	0.62	1.41	0.745	1.03	0.91	1.16	0.670	1.03	0.90	1.19	0.667	1.16	0.96	1.39	0.118
Trp	0.88	0.70	1.10	0.251	1.35	0.87	2.10	0.174	1.14	0.99	1.31	0.076	1.01	0.88	1.17	0.847	1.19	0.95	1.48	0.133
Tyr	1.21	0.96	1.52	0.102	1.02	0.69	1.52	0.915	1.18	1.02	1.36	0.023	1.16	0.99	1.35	0.059	1.33	1.06	1.67	0.012
Val	1.66	1.28	2.15	<0.001	1.51	0.92	2.46	0.100	1.69	1.42	2.02	<0.001	1.38	1.14	1.66	0.001	1.24	0.96	1.59	0.099