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. 2017 Dec 15;7:17641. doi: 10.1038/s41598-017-18038-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mean depth of coverage for the different exons of selected genes. Blue shape represents the mean coverage for each exon. Red markers represent the mean coverage by a gene; these markers are sorted in decreasing order. (A) The 35 IEM genes included in the NBS program of the FWB. (B) Additional disorders that either are considered by different NBS initiatives worldwide or could benefit from early preventive care.