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. 2017 Dec 15;7:17651. doi: 10.1038/s41598-017-17744-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AICAR inhibits TNF-α-induced expression of CFB in RPE cells. (A) RPE cells were incubated with different concentrations of AICAR starting 1 hour prior to stimulation with TNF-α (10 ng/mL) for 24 hours. Western blot demonstrating the expression level of CFB in supernatants and cell lysates. Coomassie blue stain indicates the relative loading of the samples. (B) Densitometry analysis of CFB expression in RPE cell lysates. Representative blots are shown. *p < 0.05 compared with the TNF-α group.