Table 2.
Immunohistochemical staining profile of solitary fibrous tumors of the pleura
| Staining | All (n = 78) | Adverse outcome (n = 9) | Favorable outcome (n = 69) | p-value* |
|---|---|---|---|---|
| CD34, n (%) | 0.6 | |||
| 0 | 0 (0) | 0 (0) | 0 (0) | |
| 1 | 11 (14.1) | 2 (22.2) | 9 (13.0) | |
| 2 | 27 (34.6) | 2 (22.2) | 25 (36.2) | |
| 3 | 40 (51.3) | 5 (55.6) | 35 (50.7) | |
| Bcl-2, n (%) | 0.2 | |||
| 0 | 0 (0) | 0 (0) | 0 (0) | |
| 1 | 25 (32.1) | 3 (33.3) | 22 (31.9) | |
| 2 | 27 (34.6) | 1 (11.1) | 26 (37.7) | |
| 3 | 26 (33.3) | 5 (55.6) | 21 (30.4) | |
| Vimentin, n (%) | n/a | |||
| 0 | 0 (0) | |||
| 1 | 0 (0) | |||
| 2 | 0 (0) | |||
| 3 | 78 (100) | |||
| NAB-STAT6, n (%) | 0.86 | |||
| 0 | 3 (3.8) | 2 (22.2) | 1 (1.4) | |
| 1 | 24 (30.8) | 1 (11.1) | 23 (33.3) | |
| 2 | 35 (44.9) | 3 (33.3) | 32 (46.4) | |
| 3 | 16 (20.5) | 3 (33.3) | 13 (18.8) | |
| p53, n (%) | 0.13 | |||
| 0 | 3 (3.9) | 0 (0) | 3 (4.5) | |
| 1 | 40 (52.6) | 4 (44.4) | 36 (53.7) | |
| 2 | 28 (36.8) | 2 (22.2) | 26 (38.8) | |
| 3 | 5 (6.6) | 3 (33.3) | 2 (3) | |
| IGF2, n (%) | n/a | |||
| 0 | 0 (0) | |||
| 1 | 0 (0) | |||
| 2 | 0 (0) | |||
| 3 | 78 (100) | |||
| CD99, n (%) | 0.6 | |||
| 0 | 4 (5.1) | 1 (11.1) | 3 (4.3) | |
| 1 | 39 (50.0) | 5 (55.6) | 34 (49.3) | |
| 2 | 22 (28.2) | 1 (11.1) | 21 (30.4) | |
| 3 | 13 (16.7) | 2 (22.2) | 11 (15.9) | |
| MIB-1 proliferation index (Ki-67), median % (IQR) | 1 (1.0–3.0) | 10 (1–17) | 1.0 (1.0–2.5) | 0.044 |
| MIB-1 proliferation index (Ki-67) ≥ 10%, n (%) | 5 (6.4) | 5 (55.6) | 0 (0) | < 0.001 |
The stainings were classified as negative (0), weak (1), intermediate (2) and strong (3)
HPF high-power field, n/a not applicable
*Chi-square test or Mann-Whitney U-test as appropriate