Table 3.

Risk of screen-detected breast cancer for BMI and mammographic measures by tumor characteristics

			OPERA (95% CI)
		Cases/ controls	BMI + DA + NDA	BMI + PDA	BMI + DA	DA + NDA	PDA	DA
	ER
	BIC, AUC		659, 0.64	646, 0.64	646, 0.64	638, 0.62	625, 0.62	625, 0.62
BMI per 1 SD at age 50	Positive	188/ 537	0.95 (0.66,1.38)	0.96 (0.66,1.38)	0.96 (0.66,1.38)
	Negative	45/ 130	1.16 (0.52,2.59)	1.14 (0.51,2.54)	1.12 (0.50,2.51)
BMI per 1 SD at age 70	Positive		1.30 (1.05,1.61)	1.30 (1.05,1.60)	1.30 (1.05,1.61)
	Negative		1.08 (0.65,1.80)	1.08 (0.65,1.80)	1.09 (0.65,1.82)
			P for interaction with age = 0.39	P for interaction with age = 0.40	P for interaction with age = 0.40
			P = 0.79	P = 0.80	P = 0.82
DA per adjusted 1SD	Positive		1.16 (0.99,1.36)		1.17 (0.99,1.37)	1.16 (0.99,1.37)		1.17 (0.99,1.37)
	Negative		1.30 (0.92,1.82)		1.31 (0.92,1.85)	1.29 (0.92,1.81)		1.30 (0.92,1.84)
			P = 0.57		P = 0.56	P = 0.59		P = 0.58
PDA per adjusted 1SD	Positive			1.17 (0.99,1.38)			1.17 (0.99,1.39)
	Negative			1.36 (0.94,1.96)			1.35 (0.94,1.94)
				P = 0.46			P = 0.49
NDA per adjusted 1SD	Positive		0.99 (0.83,1.16)			0.99 (0.83,1.17)
	Negative		0.87 (0.61,1.23)			0.88 (0.62,1.24)
			P = 0.53			P = 0.55
	PR
	BIC, AUC		652, 0.65	640, 0.65	640, 0.65	634, 0.63	622, 0.62	622, 0.62
BMI per 1 SD at age 50	Positive	126/ 362	0.95 (0.63,1.43)	0.93 (0.62,1.40)	0.94 (0.63,1.42)
	Negative	106/ 301	1.10 (0.62,1.97)	1.10 (0.61,1.96)	1.07 (0.60,1.90)
BMI per 1 SD at age 70	Positive		1.48 (1.14,1.93)	1.47 (1.13,1.91)	1.48 (1.14,1.93)
	Negative		1.01 (0.74,1.37)	1.00 (0.74,1.36)	1.01 (0.74,1.37)
			P for interaction with age = 0.23	P for interaction with age = 0.21	P for interaction with age = 0.22
			P = 0.17	P = 0.17	P = 0.17
DA per adjusted 1SD	Positive		1.21 (0.99,1.48)		1.21 (0.99,1.49)	1.19 (0.97,1.46)		1.19 (0.97,1.46)
	Negative		1.18 (0.95,1.45)		1.20 (0.97,1.48)	1.17 (0.95,1.45)		1.20 (0.97,1.48)
			P = 0.84		P = 0.94	P = 0.92		P = 0.98
PDA per adjusted 1SD	Positive			1.20 (0.97,1.49)			1.18 (0.96,1.46)
	Negative			1.24 (1.00,1.54)			1.23 (0.99,1.53)
				P = 0.84			P = 0.79
NDA per adjusted 1SD	Positive		1.03 (0.84,1.27)			1.03 (0.84,1.26)
	Negative		0.88 (0.70,1.10)			0.88 (0.70,1.11)
			P = 0.30			P = 0.33
	HER2
	BIC, AUC		638, 0.66	627, 0.65	626, 0.65	619, 0.63	608, 0.63	607, 0.63
BMI per 1 SD at age 50	Positive	73/ 220	0.95 (0.56,1.63)	0.93 (0.56,1.55)	0.95 (0.56,1.60)
	Negative	153/ 431	0.94 (0.60,1.47)	0.95 (0.60,1.49)	0.94 (0.60,1.48)
BMI per 1 SD at age 70	Positive		0.91 (0.61,1.34)	0.92 (0.63,1.34)	0.92 (0.62,1.34)
	Negative		1.41 (1.11,1.79)	1.40 (1.10,1.78)	1.40 (1.10,1.79)
			P for interaction with age = 0.35	P for interaction with age = 0.38	P for interaction with age = 0.36
			P = 0.16	P = 0.17	P = 0.17
DA per adjusted 1SD	Positive		1.41 (1.08,1.84)		1.40 (1.07,1.84)	1.41 (1.08,1.84)		1.41 (1.07,1.84)
	Negative		1.13 (0.94,1.35)		1.14 (0.95,1.37)	1.13 (0.94,1.35)		1.14 (0.95,1.37)
			P = 0.18		P = 0.22	P = 0.17		P = 0.20
PDA per adjusted 1SD	Positive			1.34 (1.02,1.77)			1.35 (1.02,1.78)
	Negative			1.17 (0.97,1.41)			1.17 (0.97,1.41)
				P = 0.41			P = 0.39
NDA per adjusted 1SD	Positive		1.13 (0.85,1.50)			1.13 (0.85,1.49)
	Negative		0.91 (0.75,1.11)			0.92 (0.76,1.11)
			P = 0.22			P = 0.23
	Grade
	BIC, AUC		680, 0.65	660, 0.65	661, 0.65	647, 0.63	627, 0.63	628, 0.62
BMI per 1 SD at age 50	well differentiated	62/ 174	1.09 (0.66,1.79)	1.10 (0.67,1.80)	1.10 (0.67,1.80)
	moderately differentiated	104/ 298	0.98 (0.54,1.75)	0.99 (0.55,1.77)	0.98 (0.55,1.76)
	poorly differentiated	65/ 192	0.70 (0.34,1.44)	0.70 (0.35,1.43)	0.70 (0.34,1.44)
BMI per 1 SD at age 70	well differentiated		1.05 (0.64,1.72)	1.04 (0.64,1.70)	1.02 (0.63,1.66)
	moderately differentiated		1.35 (1.03,1.77)	1.34 (1.02,1.76)	1.35 (1.03,1.78)
	poorly differentiated		1.30 (0.93,1.82)	1.30 (0.93,1.80)	1.30 (0.93,1.82)
			P for interaction with age = 0.39	P for interaction with age = 0.40	P for interaction with age = 0.38
			P = 0.79	P = 0.77	P = 0.74
DA per adjusted 1SD	well differentiated		1.29 (0.96,1.74)		1.33 (0.98,1.79)	1.29 (0.96,1.74)		1.32 (0.98,1.79)
	moderately differentiated		1.13 (0.91,1.40)		1.14 (0.92,1.41)	1.13 (0.91,1.40)		1.14 (0.92,1.41)
	poorly differentiated		1.19 (0.90,1.56)		1.19 (0.90,1.57)	1.18 (0.90,1.56)		1.18 (0.89,1.57)
			P = 0.77		P = 0.72	P = 0.77		P = 0.73
PDA per adjusted 1SD	well differentiated			1.40 (1.02,1.90)			1.39 (1.02,1.89)
	moderately differentiated			1.16 (0.92,1.45)			1.17 (0.94,1.47)
	poorly differentiated			1.16 (0.86,1.55)			1.15 (0.86,1.54)
				P = 0.59			P = 0.62
NDA per adjusted 1SD	well differentiated		0.87 (0.64,1.20)			0.88 (0.64,1.20)
	moderately differentiated		0.97 (0.75,1.24)			0.94 (0.73,1.20)
	poorly differentiated		1.01 (0.77,1.32)			1.01 (0.77,1.32)
			P = 0.78			P = 0.80
	Size
	BIC, AUC		700, 0.67	679, 0.66	680, 0.67	667, 0.64	647, 0.64	648, 0.64
BMI per 1 SD at age 50	< 1 cm	76/ 213	0.95 (0.60,1.52)	0.96 (0.61,1.53)	0.96 (0.60,1.52)
	1–2 cm	116/ 339	0.86 (0.49,1.51)	0.87 (0.50,1.54)	0.86 (0.49,1.52)
	≥ 2 cm	49/ 141	0.83 (0.32,2.14)	0.83 (0.33,2.10)	0.79 (0.30,2.07)
BMI per 1 SD at age 70	< 1 cm		1.55 (1.05,2.28)	1.54 (1.05,2.27)	1.55 (1.05,2.27)
	1–2 cm		1.24 (0.97,1.59)	1.23 (0.96,1.58)	1.24 (0.97,1.60)
	≥ 2 cm		1.09 (0.64,1.84)	1.10 (0.65,1.85)	1.11 (0.66,1.88)
			P for interaction with age = 0.30	P for interaction with age = 0.33	P for interaction with age = 0.29
			P = 0.79	P = 0.80	P = 0.80
DA per adjusted 1SD	< 1 cm		0.92 (0.70,1.20)		0.92 (0.70,1.20)	0.91 (0.70,1.19)		0.91 (0.70,1.19)
	1–2 cm		1.22 (0.99,1.50)		1.23 (0.99,1.52)	1.21 (0.98,1.50)		1.23 (0.99,1.52)
	≥ 2 cm		1.56 (1.11,2.19)		1.58 (1.12,2.22)	1.57 (1.12,2.20)		1.59 (1.13,2.24)
			P = 0.04		P = 0.04	P = 0.03		P = 0.03
PDA per adjusted 1SD	< 1 cm			0.93 (0.71,1.22)			0.92 (0.71,1.20)
	1–2 cm			1.26 (1.01,1.57)			1.26 (1.02,1.57)
	≥ 2 cm			1.64 (1.13,2.38)			1.66 (1.14,2.40)
				P = 0.03			P = 0.02
NDA per adjusted 1SD	< 1 cm		0.99 (0.75,1.29)			1.02 (0.78,1.33)
	1–2 cm		0.94 (0.76,1.16)			0.93 (0.76,1.15)
	≥ 2 cm		0.85 (0.58,1.24)			0.83 (0.57,1.21)
			P = 0.81			P = 0.68
	Nodal status
	BIC, AUC		645, 0.65	632, 0.65	632, 0.65	625, 0.64	611, 0.63	612, 0.64
BMI per 1 SD at age 50	Positive	39/ 123	0.89 (0.30,2.69)	0.97 (0.33,2.84)	0.88 (0.29,2.68)
	Negative	190/ 539	0.93 (0.65,1.32)	0.93 (0.65,1.32)	0.93 (0.65,1.33)
BMI per 1 SD at age 70	Positive		1.61 (1.04,2.50)	1.56 (1.01,2.42)	1.61 (1.03,2.51)
	Negative		1.17 (0.94,1.46)	1.16 (0.93,1.45)	1.17 (0.94,1.46)
			P for interaction with age = 0.39	P for interaction with age = 0.46	P for interaction with age = 0.38
			P = 0.41	P = 0.45	P = 0.43
DA per adjusted 1SD	Positive		1.79 (1.22,2.62)		1.78 (1.21,2.61)	1.76 (1.22,2.56)		1.78 (1.22,2.59)
	Negative		1.11 (0.94,1.30)		1.12 (0.95,1.31)	1.11 (0.94,1.30)		1.11 (0.95,1.31)
			P = 0.02		P = 0.02	P = 0.02		P = 0.02
PDA per adjusted 1SD	Positive			1.85 (1.22,2.79)			1.84 (1.23,2.76)
	Negative			1.13 (0.96,1.34)			1.13 (0.96,1.34)
				P = 0.02			P = 0.02
NDA per adjusted 1SD	Positive		0.86 (0.59,1.27)			0.87 (0.59,1.29)
	Negative		0.96 (0.81,1.13)			0.95 (0.81,1.13)
			P = 0.63			P = 0.67

Abbreviations: AUC area under the receiver operating characteristic curve, BIC Bayesian information criterion, BMI body mass index, CI confidence interval, DA dense area, NDA non-dense area, OPERA Odds per Adjusted Standard Deviation, PDA percent dense area, SD standard deviation

All of the estimates from conditional logistic regression are adjusted for age at mammogram