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. 2017 Dec 11;11:391. doi: 10.3389/fncel.2017.00391

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Copyright © 2017 Lin, Wang, Chen, Zhuang, Ke, Xiao and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methylene blue mitigates the acute post-SCI neuroinflammation. (A) mRNA levels of indicated molecules at different time points post SCI. N = 6 per group. (B) Infiltration of CD3⁺ T cells and Gr⁺ granulocytes into injured spinal cords. Left: representative flow cytometry dot plots. Right: statistics. N = 5 per group. V: vehicle; M: methylene blue treatment. *p < 0.05; ***p < 0.001 in comparison with sham-vehicle group. ^#p < 0.05 in comparison with the corresponding vehicle group of each time point.