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. 2017 Dec 11;11:391. doi: 10.3389/fncel.2017.00391

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Copyright © 2017 Lin, Wang, Chen, Zhuang, Ke, Xiao and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methylene blue inhibits cell apoptosis in injured spinal cords and improves function recovery. (A,B) Terminal deoxynucleotidyl transferase dutp nick end labeling (TUNEL) staining indicating cell apoptosis in spinal cords 24 h and 72 h post SCI. Fluorescent images are shown in (A). Statistics of the proportion of apoptotic cells were shown in (B). N = 4 per group. (C) BBB score. N = 10 per group. V: vehicle; M: methylene blue treatment. *p < 0.05 in comparison with “24 h” vehicle group. ^#p < 0.05 in comparison with the corresponding vehicle group of each time point.