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. 2017 Dec 11;11:391. doi: 10.3389/fncel.2017.00391

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Copyright © 2017 Lin, Wang, Chen, Zhuang, Ke, Xiao and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of low dose of methylene blue on SCI. Rats received methylene blue at a lower dosage (2 mg/kg body weight) before and after SCI. (A) mRNA levels of indicated pro-inflammatory mediators in T12 spinal cord 6 h after SCI. N = 3 per group. (B) TUNEL staining indicating cell apoptosis in spinal cords 24 h post SCI. Left panel: fluorescent images. Right panel: statistics of TUNEL-positive cells. N = 4 per group. (C) BBB score. N = 6 per group. (D) Concentrations of indicated cytokines in T12 spinal cord lysates 6 h post SCI. N = 3 per group. V: vehicle; M (low): methylene blue at low dose; M (high): methylene blue at high dose. *p < 0.05; **p < 0.01 in comparison with vehicle group.