Table 2.
Univariate and multivariate Cox regression analysis
| Univariate HR (95% Cl) |
Multivariate | ||
|---|---|---|---|
| Model 1 HR (95% Cl) |
Model 2 HR (95% Cl) |
||
| Age | 0.999 (0.976–1.022) | 0.996 (0.970–1.023) | 0.998 (0.972–1.025) |
| Female | 1.266 (0.906–1.770) | 1.152 (0.797–1.665) | 1.162 (0.8031–1.682) |
| Education | 0.961 (0.907–1.019) | 0.954 (0.900–1.011) | 0.961 (0.906–1.020) |
| APOE ε4 carrier | 1.290 (0.896–1.858) | 0.996 (0.674–1.470) | 1.031 (0.700–1.520) |
| Cognition | |||
| MMSE | 0.821 (0.748–0.901)b | NI | NI |
| CDR SB | 1.593 (1.347–1.883)b | 1.526 (1.276–1.824)b | 1.531 (1.279–1.832)b |
| ADAS-cog 11 | 1.118 (1.080–1.157)b | 1.101 (1.061–1.144)b | 1.104 (1.063–1.147)b |
| CSF markers | |||
| CSF t-tau* | 1.003 (1.000–1.006)a | NI | NI |
| CSF p-tau** | 1.012 (1.006–1.019)b | 1.006 (1.000–1.013) | 1.006 (1.000–1.013) |
| MRI | |||
| MTA | 1.682 (1.203–2.352)a | 1.424 (0.997–2.034)a | NI |
| PA | 2.244 (1.497–3.364)b | 1.895 (1.239–2.897)b | NI |
| Atrophy pattern | |||
| No atrophy | Reference | NI | Reference |
| MTA only | 2.998 (1.443–6.227)a | NI | 3.178 (1.520–6.645)b |
| PA only | 3.126 (1.666–5.864)b | NI | 3.209 (1.693–6.080)b |
| Both MTA and PA | 3.814 (2.045–7.110)b | NI | 3.598 (1.909–6.783)b |
* Data for 7 subjects were not available
** Data for 1 subject were not available
a p < 0.05
b p < 0.001
Model 1: adjusted for MTA, PA, age, sex, education, APOE ε4 carrier, ADAS-cog 11, CDR SB, and CSF p-tau
Model 2: adjusted for MRI atrophy pattern (no atrophy, MTA only, PA only, both MTA and PA), age, sex, education, APOE ε4 carrier, ADAS-cog 11, CDR SB, and CSF p-tau
ADAS-cog Alzheimer’s Disease Assessment Scale-cognitive subscale, CDR SB Clinical Dementia Rating Sum of Boxes, CI confidence interval, CSF cerebrospinal fluid, HR hazard ratio, MMSE Mini Mental State Examination, MRI magnetic resonance imaging, MTA medial temporal lobe atrophy, NI not included, PA posterior atrophy, p-tau tau phosphorylated at threonine 181, t-tau total tau