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. 2017 Dec 16;7:71. doi: 10.1186/s13578-017-0197-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Cell viability by Alamar blue® of HKCSCs, 769-P and Caki-1 cells treated with various doses of sunitinib (a) reduces overtime. Only HKCSCs are resistant to sorafenib in hypoxia, marked rSH (b) and to axitinib in normoxia, marked rAN (c) while 769-P and Caki-1 remain sensitive to treatment as indicated for 6 days (d). Graphs show the % of Alamar blue® reduction which indicates the number of living (metabolically active) cells. Statistically significant results are marked with * when P < 0.001 (ANOVA test). Two graphs marked with a square show resistant cell lines. Error bars presented as ± SD