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. 2017 Dec 13;12:8779–8799. doi: 10.2147/IJN.S150196

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© 2017 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Systemic toxicity of PTX-CMs.

Notes: (A) Body weight changes after male ICR mice had received signal injections of PBS and PTX-CMs at PTX dose of 30 mg/kg. (B–G) Indicators of hepatic and renal functions in toxicity assay measured at 14 days posttreatment. Data are represented as mean ± SD (n=10). (H) H&E staining of major organs after single injection of PBS and PTX-CMs at PTX dose of 30 mg/kg. Magnification ×400.

Abbreviations: PTX-CMs, paclitaxel-loaded sodium cholate and monomethoxy(polyethylene glycol)-block-poly(d,l-lactide) micelles; TP, total protein; Alb, albumin; Glob, globulin; T-Bil, total bilirubin; BUN, blood urea nitrogen; A/G, Alb/Glob; UA, uric acid; ALT, alanine transaminase.