Table 1.

Key structures affecting solithromycin activity

Structure	Position	Activity
Ketone (lack of cladinose group)	C3	Resistance to inducible MLSB target modification Removal of steric hindrance with methylated S23 domain V binding site
Aromatic side chain	C11, 12	Hydrogen bond acceptor for binding site at S23 domain II
Fluorine	C2	Third binding site to 23S rRNA Prevents enolization of C3 ketone

Note: Data from Van Bambeke9, Fernandes et al14, Llano-Satelo et al29, Juda et al30, and Bertrand et al.31

Abbreviation: MLSB, macrolide–lincosamide–streptogramin B.