FIGURE 1.

The mechanism of stress-triggered oxidative DNA damage. ER stress and cytotoxic agents trigger translocation and assembly at the nuclear envelope of MGST2-based biosynthetic machinery of LTC₄ (black arrows). The two LTC₄ receptors CysLT1 and CysLT2 translocate from the cytoplasmic membrane (and the ER) to the nuclear envelope as well (blue arrows). Binding of LTC₄ to its receptors triggers translocation of NOX4 from the ER and mitochondria to the nucleus, resulting in nuclear accumulation of reactive oxygen species and subsequent oxidative DNA damage (red arrows).