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. 2016 Jun 7;8(61):102852–102867. doi: 10.18632/oncotarget.9913

Figure 1. CS-A primary fibroblasts are characterized by altered mitochondrial morphology and present increased levels of oxidative damage in nuclear but not in mitochondrial DNA.

Figure 1

A. Distribution of cells according to mitochondrial morphology in primary fibroblasts strains from two normal (N2RO and N3RO) and three CS-A (CS6PV, CS7PV and CS24PV) donors. The reported values represent the mean ±SEM of four independent experiments; *p < 0.01, **p < 0.001 calculated within each morphological category (tubular, intermediate, fragmented) for normal versus CS-A cells. B. Basal levels of 8-OH-Gua measured as its nucleoside 8-hydroxy-2’-deoxyguanosine (8-OH-dG) by using HPLC-ED in nuclear and mitochondrial DNA of normal (N2RO) and CS-A (CS6PV) primary fibroblasts. Bars represent SD; *p < 0.05 normal versus CS-A cells.