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. 2016 Jun 7;8(61):102852–102867. doi: 10.18632/oncotarget.9913

Figure 8. Parkin overexpression decreases apoptotic Bax at mitochondria; a model of the consequences of redox unbalance in CS-A cells.

Figure 8

A., B. Quantification of Bax positive cells in A. CS3BE and CS3BE-wtCSA and B. normal (N2RO) and CS-A (CS24PV) in primary fibroblasts before and after Parkin overexpression; *p < 0.01. Right: immunofluorescence analysis of BAX and OXPHOS CII localization before and after Parkin overexpression. C. CS-A cells present increased levels of ROS/RNS. Consequently, DRP1 is hyperactivated (pDRP1) and leads to excessive fission. Parkin overexpression exerts an anti-apoptotic effect via elimination of the damaged mitochondria.