Skip to main content
. 2017 Nov 1;8(61):102868–102879. doi: 10.18632/oncotarget.22263

Figure 5. Effects of A69 on MDR1 gene expression and the TIC population.

Figure 5

(A) The doxorubicin-induced MDR1 gene expression in MMTV-PyMT;ApcMin/+ cells is inhibited by A69. Expression is normalized to 18s rRNA. (B) Representative FACS analysis of MMTV-PyMT;ApcMin/+ cells treated with solvent control or A69. (C) Quantification of Aldefluor assay in MMTV-PyMT;ApcMin/+ and MMTV-PyMT;Apc+/+ cells treated with solvent control or A69. Data are shown as the shift in gated events between test and control samples. Control samples were treated with an inhibitor DEAB. Each experiment was repeated 3 times and data are shown as means +/- SD; *P < 0.05 compared to solvent control, **P < 0.05 when comparing MMTV-PyMT;ApcMin/+ vs MMTV-PyMT;Apc+/+ cells.