Table 3. Non-synonymous somatic variants identified in PB-DLBCL samples.

Sample	Position	Ref/Alt	Gene	Function	Exon	CDS change	aa change
1	6:37140780	G/A	PIM1	missense	exon5	c.G616A	p.V206M
	6:106536093	C/CTCCA	PRDM1	frameshift_variant	exon2	c.60_61insCCGGCT	p.Ser21fs
3	16:3820828	G/A	CREBBP	missense	exon14	c.C2623T	p.P875S
5	17:62006799	A/G	CD79B	missense	exon5	c.T586C	p.Y196H
	3:38182641	T/C	MYD88	missense	exon5	c.T794C	p.L265P
	6:37138405	C/A	PIM1	missense	exon1	c.C54A	p.N18K
	6:37138427	G/A	PIM1	missense	exon1	c.G76A	p.A26T
	6:37139097	G/A	PIM1	missense	exon4	c.G437A	p.S146N
	6:37139180	C/T	PIM1	missense	exon4	c.C520T	p.L174F
	6:138200190	C/A	TNFAIP3	stopgain	exon7	c.C1608A	p.C536X
6	12:49420433	G/A	KMT2D	missense	exon48	c.C15316T	p.R5106C
	3:38182641	T/C	MYD88	missense	exon5	c.T794C	p.L265P
7	7:2978320	C/T	CARD11	missense	exon7	c.G1010A	p.R337Q
	3:38182641	T/C	MYD88	missense	exon5	c.T794C	p.L265P
8	7:2987341	G/A	CARD11	missense	exon3	c.C88T	p.R30W
	6:37139033	C/T	PIM1	missense	exon4	c.C373T	p.P125S
9	17:62006797	G/C	CD79B	stopgain	exon5	c.C588G	p.Y196X
	6:106536235	G/A	PRDM1	missense	exon2	c.G202A	p.D68N
10	6:41903731	G/A	CCND3	stopgain	exon5	c.C826T	p.Q276X
	6:138200458	C/CT	TNFAIP3	frameshift_variant	exon7	c.1876_1877insT	p.Leu626fs
11	11:108172446	G/A	ATM	stopgain	exon35	c.G5249A	p.W1750X
12a	11:108119789	C/T	ATM	missense	exon9	c.C1195T	p.H399Y
	7:140482915	G/A	BRAF	missense	exon10	c.C1220T	p.P407L
	16:3788614	G/A	CREBBP	missense	exon26	c.C4340T	p.T1447I
	3:38182641	T/C	MYD88	missense	exon5	c.T794C	p.L265P
	6:37138401	G/A	PIM1	missense	exon1	c.G50A	p.C17Y
	6:37139039	C/T	PIM1	stopgain	exon4	c.C379T	p.Q127X
	17:40476822	G/A	STAT3	stopgain	exon17	c.C1507T	p.Q503X
12b	3:38182641	T/C	MYD88	missense	exon5	c.T794C	p.L265P
	6:37138625	C/G	PIM1	stopgain	exon2	c.C159G	p.Y53X
	6:37138946	G/C	PIM1	missense	exon4	c.G286C	p.V96L
	6:37139210	C/T	PIM1	missense	exon4	c.C550T	p.L184F
13	7:2977612	A/T	CARD11	missense	exon8	c.T1072A	p.C358S
	17:62006647	A/G	CD79B	missense	exon6	c.T629C	p.I210T
	17:62006680	A/T	CD79B	missense	exon6	c.T596A	p.L199Q
	3:38182641	T/C	MYD88	missense	exon5	c.T794C	p.L265P
	6:37138808	G/T	PIM1	splice_donor_variant
	6:37138597	TGGGCAGCGGCG/T	PIM1	frameshift_variant	exon2	c.132del11	p.Leu44fs
	6:37139029	CGAGCCGGT/C	PIM1	frameshift_variant	exon4	c.370delGAGCCGGT	p.Glu124fs
	6:37139210	C/T	PIM1	missense	exon4	c.C550T	p.L184F
	16:81929465	C/T	PLCG2	missense	exon13	c.C1126T	p.R376W
	6:106536324	G/C	PRDM1	missense	exon2	c.G291C	p.E97D
	19:1622393	C/T	TCF3	missense	exon9	c.G571A	p.E191K
14	12:49440169	C/T	KMT2D	missense	exon16	c.G4457A	p.G1486D
	12:49433401	C/T	KMT2D	splice_acceptor_variant	intron31
	6:37138424	C/G	PIM1	missense	exon1	c.C73G	p.L25V
15	6:37138769	C/T	PIM1	missense	exon3	c.C202T	p.H68Y
	6:37138976	C/T	PIM1	missense	exon4	c.C316T	p.L106F
16	3:38182641	T/C	MYD88	missense	exon5	c.T794C	p.L265P
	6:37138354	G/A	PIM1	start_lost	exon1	c.G3A	p.M1I
	6:37138916	G/C	PIM1	missense	exon4	c.G256C	p.V86L
	6:37139204	C/T	PIM1	missense	exon4	c.C544T	p.L182F

Ref, reference base; Alt, altered base; CDS, coding sequence; aa, aminoacid.