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. 2017 Oct 26;8(61):102923–102933. doi: 10.18632/oncotarget.22084

Figure 3. GUCY2C opposes ER stress balancing active and reserve ISCs.

Figure 3

(A, B) Quantification of crypt ER stress marker expression, relative to tubulin, in Gucy2c+/+ and Gucy2c–/– mice (n = 3). (C, D) Grp78 (BiP) expression in crypts (*) of Gucy2c+/+ mice, and Gucy2c–/– mice before and after treatment with TUDCA or 8Br-cGMP. (E, F) Quantification of crypt Lgr5+GFP+ and Bmi1+ cells in Gucy2c+/+ and Gucy2c–/– mice following oral TUDCA for 3 d. *p < 0.05; ***p < 0.001; ns, not significant. Bar in C represents 20 µm.