Figure 4. Maintenance of ISCs by GUCY2C contributes to regenerative responses following radiation-induced intestinal injury.

Lgr5-EGFP-Cre-Gucy2c^+/+ and –Gucy2c^–/– mice received 10 Gy of irradiation and the dynamics of (A–B) viable crypts, (C) GFP⁺Lgr5⁺ active stem cells, and (D) Bmi1⁺ reserve stem cells were quantified over the subsequent 3 days. Bar in B represents 100 µm.