Table 3. Gene set analysis of 11 SPOP-mutated PCa patients was performed by KEGG database.

Pathway name	Candidates contained
Thyroid hormone synthesis*	19
Valine, leucine and isoleucine degradation	14
Oxidative phosphorylation	26
Cysteine and methionine metabolism	10
Pyrimidine metabolism	19
Glycine, serine and threonine metabolism	10
Alanine, aspartate and glutamate metabolism	9
Arachidonic acid metabolism*	12
Fatty acid degradation	10
Purine metabolism	26
Fructose and mannose metabolism	8
Pyruvate metabolism	9
Butanoate metabolism	7

^*Down-regulated metabolic pathways in SPOP mutated PCT tissues. Others were upregulated metabolic pathways (non-labeled).

The results were calculated by consensuspathdb online software. 3766 differential transcripts were used for gene set analysis, of which 1840 transcripts were upregulated and 1926 transcripts were down-regulated. Candidates contained indicates the number of altered transcripts involved in these metabolic pathways in our study. The altered metabolic pathways with p < 0.01 are listed.