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. 2017 Sep 21;8(61):103261–103273. doi: 10.18632/oncotarget.21143

Figure 4. Chemotherapeutic treatments generates more cancer stem-like cells.

Figure 4

(A) Stem cells with CD44 or ALDH1 surface marker were awakened from hibernation after massive proliferative cancer cells being perished during the anticancer treatment. (B) Stem cells number became greater in patients received neoadjuvant chemotherapy, compared to that of patient received surgeries without neoadjuvant therapy, but no significant correlation was detected between ALDH1 and CD44 intensity. (C) Fluorouracil treatment increased the sphere formation efficiency of breast cancer stem-like cells. (D) Both Fluorouracil and NUMB inhibition facilitates the sphere forming ability, however, the enforced miR-129 and NICD inhibition significantly abolished the oncogenic promotion of Fluorouracil on self-renewing ability of cancer stem-like cells.