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. 2017 Oct 13;8(61):103393–103409. doi: 10.18632/oncotarget.21900

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Copyright: © 2017 Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Agonist assay of the HEK293/Gα15/ETB cell line. Dose-response curve for ET-1, with EC50 value of 11.6 nM. (B) Antagonist assay of the HEK293/Gα15/ETB cell line. Dose-response curve for bosentan, with IC50 value of 616.5 nM. (C) Antagonist assay of DH on HEK293/Gα15/ETB cell line. Dose-response curve for DH, with IC50 value of 25.67 μL/mL.