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. 2017 Oct 13;8(61):103393–103409. doi: 10.18632/oncotarget.21900

Figure 9. Schematic representation of DH-mediated protection from ET-1-induced CH on hiPS-CMs.

Figure 9

Signaling network after DH treatment. DH attenuated CH by blocking ETBR and AT1R, and then suppressing the downstream signaling pathways related to cell cycle, RNA processing, cytoskeleton and mitochondria. Blue nodes present the key proteins related to CH, and purple nodes presents proteins related to CH. Green node presents the biological processes.