Table 1. The relationship between NLR/Alb and clinical characteristics for ESCC.
| Total (N = 329) (n, %) |
NLR/Alb ≤ 0.1 (N = 238) (n, %) |
NLR/Alb > 0.1(N = 91) (n, %) |
P-value | |
|---|---|---|---|---|
| Sex Male Female |
287 (87.2) 42 (12.8) |
207 (87.0) 31 (13.0) |
80 (87.9) 11 (12.1) |
0.820 |
| Age (years) ≤ 60 > 60 |
190 (57.8) 139 (42.2) |
137 (57.6) 101 (42.4) |
53 (58.2) 38 (41.8) |
0.911 |
| Tumor length (cm) ≤ 3.0 > 3.0 |
92 (28.0) 237 (72.0) |
82 (34.5) 156 (65.5) |
10 (11.0) 81 (89.0) |
< 0.001 |
| Tumor location Upper Middle Lower |
19 (5.8) 154 (46.8) 156 (47.4) |
14 (5.9) 117 (49.2) 107 (44.9) |
5 (5.5) 37 (40.7) 49 (53.8) |
0.345 |
| Vessel invasion Positive Negative |
51 (15.5) 278 (84.5) |
38 (16.0) 200 (84.0) |
13 (14.3) 78 (85.7) |
0.706 |
| Perineural invasion Positive Negative |
64 (19.5) 265 (80.5) |
47 (19.7) 191 (80.3) |
17 (18.7) 74 (81.3) |
0.827 |
| Differentiation Well Moderate Poor |
46 (14.0) 220 (66.9) 63 (19.1) |
32 (13.4) 164 (68.9) 42 (17.7) |
14 (15.4) 56 (61.5) 21 (23.1) |
0.422 |
| TNM stage I II III |
85 (25.8) 109 (33.1) 135 (41.1) |
77 (32.4) 83 (34.9) 78 (32.7) |
8 (8.8) 26 (28.6) 57 (62.6) |
< 0.001 |
| Adjuvant therapy Yes No |
94 (28.6) 235 (71.4) |
63 (26.5) 175 (73.5) |
31 (34.1) 60 (65.9) |
0.173 |
| NLR (mean ± SD) ≤ 4.0 > 4.0 |
3.36 ± 2.27 220 (66.9) 109 (33.1) |
2.56 ± 1.25 201 (84.5.) 37 (15.5) |
5.45 ± 2.92 19 (20.9.) 72 (80.1) |
< 0.001* < 0.001 |
| CRP (mg/l, mean ± SD) ≤ 12.0 > 12.0 |
7.42 ± 11.8 264 (80.2) 67 (19.8) |
6.20 ± 10.60 201 (84.5) 37 (15.5) |
10.6 ± 14.1 63 (69.2) 28 (30.8) |
0.007* 0.002 |
| Albumin (g/l, mean ± SD) ≤ 42.0 > 42.0 |
40.51 ± 5.30 205 (62.3) 124 (37.7) |
41.77 ± 4.85 129 (54.2) 109 (45.8) |
37.20 ± 5.04 76 (83.5) 15 (16.5) |
< 0.001* < 0.001 |
| CRP/Alb (mean ± SD) ≤ 0.1 > 0.1 |
0.19 ± 0.33 175 (53.2) 154 (46.8) |
0.15 ± 0.27 139 (58.4) 99 (41.6) |
0.30 ± 0.43 36 (39.6) 55 (60.4) |
< 0.001* 0.002 |
| GPS 0 1 2 |
194 (59.0) 95 (28.9) 40 (12.1) |
164 (68.9) 65 (27.3) 9 (3.8) |
30 (33.0) 30 (33.0) 31 (34.0) |
< 0.001 |
ESCC = esophageal squamous cell carcinoma; NLR = neutrophil lymphocyte ratio; Alb = albumin; CRP = c-reactive protein; GPS= Glasgow prognostic score Statistical methods: The chi-squared test. “*” by t-test.