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. 2017 Oct 9;8(61):103613–103625. doi: 10.18632/oncotarget.21665

Figure 3. Cell proliferative curves and survival rate of QGP-1 and NIT-1 cells with or without knockdown of PCK2 or Pck2 and treatment of mTOR inhibitors, rapamycin or RAD001.

Figure 3

(A) The cell proliferative rate was reduced by RAD001 and rapamycin for both QGP-1 and NIT-1 cells infected with vector control (shLuc). The cell proliferative rate of QGP-1 and NIT-1 cells was further decreased by RAD001 or rapamycin when PCK2 was knocked down (shPCK2 and shPck2). (B) The survival rate of QGP-1 and NIT-1 cells treated with RAD001 or rapamycin for 3 days is shown. The survival of QGP-1/shPCK2 was significantly poorer than that of QGP-1/shLuc in low and higher dose of RAD001 or rapamycin. The similar result was also seen in NIT-1 cells. T test, * P<0.05.