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. 2017 Oct 10;8(61):103657–103670. doi: 10.18632/oncotarget.21761

Figure 2. Effect of Bevacizumab treatment on glucose metabolism of GBM cells.

Figure 2

(A) Beva increased the glucose consumption of U251 and SW1088 cells after 48 hours of treatment; results are representative of three independent experiments, each one in triplicates; *p<0.05, ****p≤0.0001 Beva vs control. Western blot (B) and immunofluorescence (C) of hypoxia markers and glycolytic markers in U251 and SW1088 cells treated with 2mg/ml Beva during 48 hours. Increased HIF-1α, CAIX and GLUT1 expression was observed after treatment. The cell nucleus were counterstained with DAPI and the pictures were taken at 400x in an Olympus fluorescence microscope.