Table 2. PTC-209 and JQ1 combination treatments, inhibition rate and combination index (CI).
Cell Line | PTC-209 (µM) | JQ1 (µM) | Inhibition Rate | Combination Index (CI) |
---|---|---|---|---|
INA-6 | 0.1 | 0.05 | 0.91980 | 0.28170 |
0.1 | 0.1 | 0.92099 | 0.40982 | |
0.2 | 0.05 | 0.86716 | 0.63779 | |
0.2 | 0.1 | 0.96916 | 0.27303 | |
0.3 | 0.05 | 0.95350 | 0.41319 | |
0.3 | 0.1 | 0.93535 | 0.60423 | |
JJN3 | 0.1 | 0.05 | 0.65742 | 0.69484 |
0.1 | 0.1 | 0.82372 | 0.67699 | |
0.2 | 0.05 | 0.56127 | 1.11905 | |
0.2 | 0.1 | 0.79496 | 0.86991 | |
0.4 | 0.05 | 0.73771 | 0.91708 | |
0.4 | 0.1 | 0.81171 | 1.00260 | |
RPMI-8226 | 0.2 | 0.1 | 0.52490 | 1.13203 |
0.2 | 0.2 | 0.73503 | 0.92359 | |
0.4 | 0.1 | 0.63731 | 1.20221 | |
0.4 | 0.2 | 0.78667 | 1.03513 | |
0.6 | 0.1 | 0.94489 | 0.52199 | |
0.6 | 0.2 | 0.96883 | 0.43832 | |
LP-1 | 0.2 | 0.05 | 0.45307 | 1.10495 |
0.2 | 0.1 | 0.62035 | 1.17057 | |
0.4 | 0.05 | 0.51424 | 1.25665 | |
0.4 | 0.1 | 0.64495 | 1.32982 | |
0.6 | 0.05 | 0.80423 | 0.71373 | |
0.6 | 0.1 | 0.84470 | 0.80021 |
Combination index (CI) values were determined using CompuSyn software (ComboSyn, Inc., Paramus, NJ). CI values < 0.8; 0.8–1.2 or > 1.2 indicated synergistic, additive, or antagonistic drug activities, respectively.