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. 2017 Oct 20;8(61):103731–103743. doi: 10.18632/oncotarget.21909

Table 2. PTC-209 and JQ1 combination treatments, inhibition rate and combination index (CI).

Cell Line PTC-209 (µM) JQ1 (µM) Inhibition Rate Combination Index (CI)
INA-6 0.1 0.05 0.91980 0.28170
0.1 0.1 0.92099 0.40982
0.2 0.05 0.86716 0.63779
0.2 0.1 0.96916 0.27303
0.3 0.05 0.95350 0.41319
0.3 0.1 0.93535 0.60423
JJN3 0.1 0.05 0.65742 0.69484
0.1 0.1 0.82372 0.67699
0.2 0.05 0.56127 1.11905
0.2 0.1 0.79496 0.86991
0.4 0.05 0.73771 0.91708
0.4 0.1 0.81171 1.00260
RPMI-8226 0.2 0.1 0.52490 1.13203
0.2 0.2 0.73503 0.92359
0.4 0.1 0.63731 1.20221
0.4 0.2 0.78667 1.03513
0.6 0.1 0.94489 0.52199
0.6 0.2 0.96883 0.43832
LP-1 0.2 0.05 0.45307 1.10495
0.2 0.1 0.62035 1.17057
0.4 0.05 0.51424 1.25665
0.4 0.1 0.64495 1.32982
0.6 0.05 0.80423 0.71373
0.6 0.1 0.84470 0.80021

Combination index (CI) values were determined using CompuSyn software (ComboSyn, Inc., Paramus, NJ). CI values < 0.8; 0.8–1.2 or > 1.2 indicated synergistic, additive, or antagonistic drug activities, respectively.