Skip to main content
. 2017 Oct 10;8(61):103775–103784. doi: 10.18632/oncotarget.21790

Figure 2. Molecular analyses of the cutaneous CD4 positive T-cell lymphoma.

Figure 2

(A) Nested PCR with the primer combinations ATXN2L-3116F1/JAK2-3006R1 (lane 1) and ATXN2L-3183F1/JAK2-3044R1 (lane 2). M, 1 Kb DNA ladder (GeneRuler, Fermentas). (B) Sanger sequencing of the amplified products showed an ATXN2L-JAK2 cDNA fragment in which the fusion point was identical to that found using TopHat-Fusion. (C) Diagrams showing the ataxin-2 like protein isoform A (ATXN2L), NP_009176.2, tyrosine-protein kinase JAK2 isoform a, NP_004963.1, and the putative ATXN2L-JAK2 protein resulting from the fusion between ATXN2L (from16p11) and JAK2 (from 9p24). Arrows indicate breakpoints/fusions.