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Clones (1 X107 cells) constitutively expressing wild type LINE-1 (L1) (clone #5), a mutant L1 counterpart lacking reverse transcriptase activity (clone #13), or empty vector were mixed with matrigel and injected into 5-week old male Nu/Nu mice. (A) Tumor sizes 6-weeks after implantation. (B) Mice bearing cells expressing mutant L1. (C) Mouse weights.
